It gets down to one of two assumptions. We exist within a creation or we do not exist within a creation.
I don't know what you mean by "existing within a creation."
I am going to assume you mean that material existence is "a creation" because it was supernaturally created. If this is what you are getting at, then I would re-phrase your statement as follows:
It gets down to one of two assumptions. Either we can opt for metaphysical dualism
- that is, that there are two separate realities, a familiar, "natural" one and a hidden "supernatural" one. Or we can opt for metaphysical monism
, in which case, we hold that there is no such thing as the supernatural. The most common form of monism today is naturalism
Science does not claim that everything
can be explained. Science, being a form of methodological naturalism, makes no claims about the supernatural at all. That's why many Christians can also be scientists. Nor does science make claims about the moral or the esthethic or ultimate meaning and so forth. These claims properly belong to the domain of theology and philosophy, not science.
What science does do, is provide powerful explanations of material reality in which the supernatural "explanations" are superfluous. And contrary to your assertion that scientific explanations are dubious, I submit that much of science has been robustly confirmed.
As A.W. Tozer put it, what each of us believes about God is the most important thing in our lives because it affects everything.
I submit Tozer was wrong. This is mere projection on the part of many Christians. Because evangelicals believe that the question of God's existence is the most important question in life, they think non-theists also think the question is important. But this is simply not true. Many atheists fall out of religion without alot of thought about it. For many of us, atheism is like no longer believing in Santa Claus -- no angst.